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DNA fragmentation has a direct impact on sperm function and male fertility

Some studies suggest that NSAIDs can interfere with mitochondrial function, leading to an increase in reactive oxygen species (ROS)unstable molecules that contribute to oxidative stress

doi: 10.3390/ani10122407 48 SimmonsD

Additionally, for critically ill patients with complex conditions, particularly those with liver or renal failure, the use of glutamine via PN is not advised [73]